Premature Ovarian Insufficiency - diagnostic and therapeutic challenges

Introduction and purpose: Premature Ovarian Insufficiency (POI) is a rare but serious disease diagnosed in about 1% of women before the age 40. It characterized by hypoestrogenism an increase level follicle-stimulating hormone, which associated with menstrual disorders, pregnancy failures reduced quality life. The main causes POI include genetic background autoimmune abnormalities, as well increasingly jatrogenic factors. Care for patients focused on hormone replacement therapy infertility treatment. aim this review to discuss current treatment methods, impact early diagnosis prevention premature ovarian insufficiency, affects ability have one's own offspring. article also describes new methods that are under investigation.
 Materials methods: This literature based articles published PubMed database from 2015 2022 using following phrases: insufficiency stem cells
 State knowledge: only way treat egg donation. Currently, research being conducted achieve diagnosis, introduce reduce number iatrogenic forms POI.
 Conclusion: problem difficulty or often impossibility having their children. Egg donation does not allow transfer patient's material, available option some countries. For reason, treatment, developed.